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From Department of Cardiology, Boston Children’s Hospital, MA (S. FH prevalence was not calculated in younger children because LDL-C was not measured in NHANES participants Characteristics of the overall adult NHANES study sample and those who met criteria for probable and definite FH are described in the Table, shown as the adult US population prevalence based on NHANES weighting. For this age group, FH was defined with the use of LDL-C ≥4.9 mmol/L (190 mg/d L) exclusive of other factors because personal and family history of early ASCVD and high cholesterol were not collected in NHANES participants 12 to 19 years of age.

Anu, who had her leg amputated soon after she was born, is seen entering a school playground in Birmingham in the BBC Midlands Today footage, when her friends rush over to see her wearing the new activity prosthetic leg for the first time. The new blade, which allows Anu to run and dance, has been custom made for her thanks to a £1.5m funding injection given to the NHS last year. Because of incomplete data for some criteria of the DLC definition of FH in some adult NHANES participants, particularly LDL-C level and family history of early ACVD, a sensitivity analysis used imputation to estimate missing data. Some DLC criteria, namely genetic testing, family history of hypercholesterolemia, personal history of peripheral arterial disease, and relevant physical examination findings, were not collected in NHANES and were not considered in this analysis. The χ test was used for categorical variables, and linear regression was used for continuous variables. M.); Institute for Clinical Research and Health Policy Studies (A. We tested for whether missingness of LDL-C was associated with age, sex, personal history of early ASCVD, and family history of ASCVD and whether missingness of familial ASCVD was associated with age, sex, personal history of early ASCVD, and LDL-C value.

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Results were extrapolated to the US population using the Current Population Survey according to the NHANES analytic guidelines.

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